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BioRender Template

Senescence Associated Secretory Phenotype (SASP)

Rosalba Lopez
3+
Creator
s
An editable high resolution scientific image depicting Senescence Associated Secretory Phenotype (SASP)

Description

External stimuli, damage or stress from physiological insults, reactive oxidative species (ROS), radiation, and nutrient deprivation can activate multi-step intracellular signalling cascades that lead to epigenomic modifications or genomic damage. In turn, the genomic instability leads to irreversible cell cycle arrest, metabolic changes, lysosomal accumulation, chromatin remodelling, and a proinflammatory secretome, otherwise known as the senescence-associated secretory phenotype (SASP).
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